The distributions of B-ALL molecular subtypes across cohorts and frequencies according to age are shown in Figure 2B. We found high hyperdiploidy in 27.3%, DUX4 in 13.6%, PAX5alt in 4.5%, TCF3::PBX1 in 9.1%, ETV6::RUNX1 in 9.1%, KMT2A in 4.5%, ETV6::RUNX1-like in 9.1%, BCR::ABL1 in 4.5%, Ph-like in 9.1%, ZNF384 in 4.5%, and PAX5alt-low hypodiploidy in 4.5% of the patients (Figure 2B). The gene discussed is DUX4; the disease is acute lymphoblastic leukemia.