The frequencies of different B-ALL molecular subtypes in the MIGICCL cohort differed between age groups, with children >10 years of age harboring Ph, Ph-like, PAX5alt, DUX4, and ETV6::RUNX1-like subtypes, compared with children <10 years of age who comprised, additionally, the ZNF384, high hyperdiploidy, and ETV6::RUNX1 subtypes (Figure 2C). Here, RUNX1 is linked to precursor B-cell acute lymphoblastic leukemia.