We identified BCR (37%), TCF3 (32%), ADGRF1 (26%), FAT1 (26%), TYK2 (26%), PDGFRA (38%), SEMA6A (16%), STAT2 (16%), FLT3 (11%), NRAS (11%) and SETD2 (11%) recurrently with a missense variant that occurred across different B-ALL molecular subtypes and cannot be regarded as specific to any B-ALL molecular subtype; we only identified mutually exclusive missense variants in PDGRFA in the patients with the DUX4 subtype (Figure 3). Here, SETD2 is linked to precursor B-cell acute lymphoblastic leukemia.