According to transcriptomic and metabolomic analyses, the primary regulatory processes of isovitexin in liver fibrosis may be the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and the glutathione (GSH) metabolic pathway, also confirming that miR-21 is a crucial node in the isovitexin regulation of the PI3K/Akt signaling pathway and GSH metabolic pathway [19]. The gene discussed is AKT1; the disease is Hepatic fibrosis.