SIRT1 and injury: The protective effect of vitexin against ethanol-induced liver damage was closely linked to the Sirt1/p53-mediated apoptosis pathway, as evidenced by the fact that vitexin inhibited serum TG and TC levels and significantly improved ethanol-induced ALD [44], and its protective effect against ethanol-induced liver injury was closely linked to the Sirt1/p53-mediated apoptosis pathway, as Sirt1 could remove the acetyl group of p53, reduce the transfer of p53 from cytoplasm to mitochondria, inhibit the release of mitochondrial pro-apoptotic proteins, and ultimately restrict apoptosis [45].