After the overexpression of PSME2, it was found that it upregulated the IL-17 signaling pathways, chemokines signaling pathways, Corona disease COVID-19, and transcriptional mis-regulation in cancer (Figure 6F), while Spearman correlation analysis showed that they were positively correlated with the abundance of immune cells (Figure 6M), suggesting that it plays a role in various immune and inflammation responses. Here, PSME2 is linked to cancer.