Studies have shown that the T cell-specific adopter protein (TSAd) encoded by the SH2DA2 gene necessary for the activation of T cell [37,38] was required for c-Src activation, vascular endothelial growth factor receptor 2 (VEGFR2)/c-Rous sarcoma (c-Src) interaction, and promoted vascular permeability in tumor vessels [39,40]. This evidence concerns the gene SH2D2A and neoplasm.