As for PASK, it showed a high expression level in tumor tissue and showed a negative correlation with the abundance of immune cells (Figure 6K); it was found that PASK downregulated defense response and antimicrobial humoral response, with downregulation in defense response to a Gram-positive bacterium (Figure 6D), indicating that high expression of PASK in tumor tissue was not suppressed by immune cells. The gene discussed is PASK; the disease is neoplasm.