TREM2 and Alzheimer disease: Several other genes were associated with an enhanced risk of developing AD or were proposed to have a role in AD pathogenesis [32] (e.g., the Triggering receptor expressed on myeloid cells 2 (TREM2) [42], the ATP-binding cassette subfamily A member 7 (ABCA7) [43], the Bridging integrator 1 (BIN1) [44], etc.).