Likewise, the transcriptional activator AUTS2 [76,77], KCNH7 potassium channel variants [78,79], lysine methyltransferase SETD2 (which is also downregulated in mice) [53,80,81], and USP7 [82,83], among others, are induced by rest, and their mutations are associated with a variety of neurodevelopmental disorders. The gene discussed is USP7; the disease is neurodevelopmental disorder.