In addition, genes involved in learning and memory (ARHGAP39 [48] and HERC1 [49]), intellectual disability (SOBP [50]), or autism (NF1), whose mutations cause neurodevelopmental, behavioral, learning, and motor abnormalities [51,52], are repressed by exercise and normalized or slightly induced upon subsequent rest (Figure 5B). The gene discussed is ARHGAP39; the disease is Intellectual disability.