Moreover, exposure to danger signals, such as tumor-derived double-stranded DNA (dsDNA), promotes DC maturation and the upregulation of key immunostimulatory molecules, including co-stimulatory ligands (CD80 and CD86) and cytokines such as interleukin-12 (IL-12), which supports the differentiation of cytotoxic T lymphocytes. The gene discussed is CD86; the disease is neoplasm.