To summarize, we identified CNV-associated cognitive impairments involving PSEN1 (exons 1, 9, and presumably 12), GRN (exons 1, 6, 12), and MAPT (exons 2 and 8), which is consistent with prior findings by Xiao et al. [29] reporting pathogenic PSEN1 variants in exons 4–8, 11, and 12. This evidence concerns the gene PSEN1 and Cognitive impairment.