Impaired lipoprotein remodeling hampers the transition from pre-β-HDL to mature HDL; uremic retention of apolipoprotein C-III (Apo C-III) and pre-β-HDL further inhibits LPL-mediated TG clearance, an effect amplified by secondary hyperparathyroidism [48,49,50]. This evidence concerns the gene APOC3 and secondary hyperparathyroidism.