On the one hand, excessive ectopic lipid accumulation and insulin resistance unify MAFLD and CKD pathogenesis, promoting their oxidative stress, inflammation, and fibrosis through shared pathways, such as dyslipidemia induced by the impairment of related enzymes and receptors, activation of inflammatory signals mediated by cell senescence, ALEs, ox-LDL, CD36, and RAGE/TLR-4, and insulin signaling impairment driven by PPAR signals and LCFA/DAG/ceramide. The gene discussed is TLR4; the disease is metabolic syndrome.