REN and atherosclerosis: Hypertension, in turn, contributes to the development of atherosclerosis through vascular endothelial dysfunction and excessive activation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS) [15] Amyloid deposits (which can be found in different life forms from yeast [16,17] to mammals [18] could be one of the under investigated topics in the context of its potential effects on atherosclerosis development [19].