Within PTCH1, several variants, 1183, V1083Wfs4, X844_splice, L490, R459Lfs49, X195_splice, and X132_splice, were predicted to be oncogenic LOF mutations according to OncoKB, further supporting the central role of Hh signaling in BCC pathogenesis in the Korean population. The gene discussed is PTCH1; the disease is skin basal cell carcinoma.