APOE and dementia: However, we observed a similar allelic effect and significance: rs6559700 was associated with decline in attention in the APOE 3/3 group (p = 1.38 × 10−8, β = −0.28); rs116379916 was associated with decline in global function in the APOE 3/3 group (p = 2.57 × 10−9, β = −0.46), and rs13187183 was associated with the decline in language (p = 1.025 × 10−8, β = 0.69) in the APOE4 carrier group, indicating that these are not driven by MCI/incident dementia.