Due to numerous indications in recent years that SHIP1 is an important negative regulator of the PI3K/AKT/mTOR signaling pathway and BCR-dependent signaling, we take a closer look at its tumor suppression, its expression in the various subtypes of ALL, its regulation, and its role in the progression of ALL, and summarize these areas in this review article. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.