High SHIP1 expression in both Ph-positive and ETV6-RUNX1 B-ALL cells could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for AIC activation, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection [11,187]. Here, INPP5D is linked to precursor B-cell acute lymphoblastic leukemia.