In addition, the constitutive activation of the T-ALL oncogenes NOTCH1 and TAL1 by mutation or translocation often leads to a strong misregulation of the expression of various microRNAs (miR-19b, miR 20a, miR-26a, miR-92, and miR-223), which jointly downregulate the expression of Ikaros, PTEN, and FBXW7 [200,201]. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.