Considering the crucial role of MERTK and other members of TAM RTKs in creating an immunosuppressive microenvironment and enhancing the survival of cancer cells, it can be suggested that targeting these kinase members in a time-controlled and cancer-specific manner could be beneficial in improving cancer patients’ disease outcome while not disturbing the homeostatic balance of the immune system [81]. The gene discussed is MERTK; the disease is cancer.