Comparing protein kinase-mediated signal transduction pathways associated with the immunosuppressive phenotype in MDSCs derived from the same murine species but generated under different modeling systems, such as self-limited inflammatory conditions (e.g., acute liver injury) and MDSCs generated in sustained, chronic inflammatory contexts (e.g., tumor), may provide a clearer picture of the molecular mechanisms underlying the potent immunosuppressive functions of MDSCs in distinct pathophysiological contexts [67,80]. Here, WEE1 is linked to injury.