ERBB2 and metastatic neoplasm: Those patients with high TAM infiltration (>250 macrophages) exhibited a higher frequency of grade III tumors (p<0.0001; Figure 4G), increased proliferative activity (p<0.0001; Figure 4H), metastatic disease at diagnosis (p=0.0002; Figure 4I), and were predominantly classified as Luminal B or HER2+/TN subtypes (p<0.0001; Figure 4J).