Dogs with high macrophage counts were more likely to have poorly differentiated tumors (grade III, p=0.0027; Figure 4B), high cellular proliferation indices (>20%, p=0.0023; Figure 4C), advanced clinical staging with metastatic disease (p=0.0034; Figure 4D), and non-luminal molecular subtypes (Luminal B or HER2+/TN, p=0.0016; Figure 4E). This evidence concerns the gene ERBB2 and metastatic neoplasm.