Taking this as a basis, the use of L-asparaginase in chemotherapies was implemented and it was shown that in tumor cells the hydrolysis of asparagine by L-asparaginase drains all circulating asparagine, resulting in the depletion of serum asparagine [28], leading to cancer cell starvation and ultimately to DNA breaks, cell cycle arrest, and apoptosis. Here, ASPG is linked to cancer.