Taking into account that our previous study on the same group of patients demonstrated a downregulation of lncRNA MALAT1 in GDM, the observed upregulation of miR-21-5p was expected, since MALAT1 acts as a microRNA sponge for miR-21-5p and the functional significance of this interaction has been previously demonstrated in the context of GDM [46,68]. This evidence concerns the gene MALAT1 and gestational diabetes.