Abnormal expression of Lck and NF-κB have been associated with various autoimmune diseases and malignancies, including systemic lupus erythematosus (SLE) [67], rheumatoid arthritis (RA) [68], acute T cell lymphocyte leukemia (T-ALL) [69] and cholangiocarcinoma [70]. The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.