USP7 and central nervous system cancer: It has also been used to detect complex CNVs such as JAK1-PAK2, JAK1-PVT1, JAK1-MYOCD, JAK1-TIMM21, USP7-TIMM21, and JAK1-Chr22 CNVs in whole blood-derived ovarian cancer samples, EGFR, CDKN2A, and BRAF CNV in glioma tissues, as well as FGFR2 CNV in colorectal and gastric adenocarcinomas [19,26,50,51,52,53,54,55].