In another study, macrophages were cotransduced with a hypoxia-regulated E1A/B construction and an E1A-dependent oncolytic Adv proliferation was also restricted to prostate tumor cells by prostate-specific promoter elements from the tumor-associated receptor protein (TARP), prostate-specific antigen (PSA), and prostate-specific membrane antigen (PSMA) genes. This evidence concerns the gene KLK3 and prostate neoplasm.