Spatial transcriptomics in glioblastoma revealed a progressive decline in hypoxia-responsive genes (e.g., vascular endothelial growth factor A (VEGFA)) and glycolytic genes (e.g., glucose transporter 1 (GLUT1)) with increasing distance from necrotic regions [8], demonstrating how metabolic adaptation correlates with microenvironmental topography. This evidence concerns the gene VEGFA and glioblastoma.