KISS1 and neoplasm: It has been identified that OXPHOS inhibition enhances metastatic potential in specific biological contexts due to the mutational inactivation of tumor suppressors, such as the p53 mutation affecting mitochondrial function [106,107], EMT-related repression of cytochrome c oxidase via Snail [108], and deletion of KiSS-1 metastasis-suppressor (KISS1)-mediated PGC1α regulation [109].