HK2 and neoplasm: Hypoxic tumor cores exhibit glycolytic dependency mediated by HIF-1α stabilization, targetable through HIF-1α inhibitors [144] (adamantane derivatives [145], MO-2097 [146], NLG207 [147], NB-5-MT [148]), combined with glycolytic enzyme blockade (HK2 inhibitor PF-04691502 [149], LDHA inhibitor FX-11 [150,151]).