TP53 and cancer: According to the Cancer Cell Line Encyclopedia (CCLE) database, there are 786-0 mutates in the PTEN and TP53 (p.R248W) genes, A498 mutates in the SETD2 (p.V2536fs) and MLL3 (p.G2986D) genes, and Caki-1 mutates in SETD2 and MET (p.V1238I), [26].