VEGFA and cancer: There were 102 Reactome pathways enriched for the U-EV proteome of the GS 8–9 patients and related to stress and immune responses, mRNA stability, signalling cascades (including interleukins, which are a known risk factor for cancer [62]), the cell cycle and angiogenesis—including VEGF, which is associated with tumour grade, metastasis, and prognosis [63].