TNF and diabetes mellitus: Over and above these roles in tumor progression, the TLR4/MyD88/NF-κB signaling pathway induces production of tumor necrosis factor-α, interleukin-6, and monocyte chemoattractant protein-1, all of which are associated with other conditions such as heart- and liver-related complications of Type-2 Diabetes Mellitus [24] and, interestingly, with Parkinson’s disease [18].