In addition, IL-1β is known to regulate the expression of Nuclear Factor-κB (NF-κB), which plays an important role in cancer metastasis and progression [8] and is known to regulate the expression of COX-2, the inflammatory regulator of IL-6, which in turn is responsible for cancer metastasis via increased production of intracellular adhesion molecules [ICAMs and VCAMs] [9]. The gene discussed is NFKB1; the disease is cancer.