Further, our results show that IL1-β promotion of the TLR-MYD88-NFkB-IL-6 pathway feeds back to further increase IL-1β itself, thereby creating a self-perpetuating cycle of cancer cell proliferation and metastasis., As we show here, this cycle can be challenged by IL-1RA and Tolcapone, and in this way, cancer growth and spread can be curbed. Here, NFKB1 is linked to cancer.