A reduction in αSyn accumulation in vitro may be obtained by silencing the lncRNA small nucleolar RNA host gene 14 (SNHG14)/miR-133b [293], the circular RNA circ-Pank1 [295], and NADPH oxidase 4 (NOX4) gene [268], suggesting potential translational alternative therapeutic approaches to PD. This evidence concerns the gene NOX4 and Parkinson disease.