Inhibition of VMAT2, which is expressed on synaptic vesicles of DOPAn, NE, and SE neurons and regulates the release of neurotransmitters [196]. Accordingly, dysfunction of these circuits in PD has been reported [161,189,197]. This model reproduces motor signs [161,198,199,200]; DA loss [189,199,200]; non-motor signs [161]; αSyn presence [199]; mitochondrial dysfunction and redox stress [155,161,199,201]; autophagy [155,161,199,202]; and inflammation [161,199]. This evidence concerns the gene SLC18A2 and Parkinson disease.