MPO and obesity due to melanocortin 4 receptor deficiency: In a study conducted on male albino rats fed with a high-fat diet, it was observed that the addition of curcumin to the diet caused an increase in the activity of SOD, GPX, catalase and the amount of reduced glutathione (GSH), as well as a decrease in hepatic myeloperoxidase (MPO), considered a risk marker for obesity [65].