Supporting this, the TMEM43 p.S358L missense variant—a causal mutation for arrhythmogenic right ventricular cardiomyopathy type-5 (ARVC5)—has been shown to disturb a conduction velocity at the gap and adherens junctions due to zonula occludens-1 (ZO-1) protein ablation from cardiac myocyte cell–cell junctions [34]. Here, TMEM43 is linked to Arrhythmogenic right ventricular dysplasia.