Fetal ARVC associated with double mutations p.V89M and p.R299T in TMEM43 displayed RV aneurysm with regionally decreased systolic function and ventricular arrhythmias with frequent PVCs, left bundle branch block, and epsilon waves in the right-sided leads on electrocardiogram (ECG) tracings [112]. The gene discussed is TMEM43; the disease is Arrhythmogenic right ventricular dysplasia.