While the presence or overexpression of TMEMs is generally considered a risk factor for many cancers, genetic analysis has shown that the TMEM88 protein has diverse functions in cancers, such as protective effects in gliomas [158], while it promotes invasion and metastasis in lung cancers and predicts the survival and palindromia time of hepatocellular carcinoma (HCC) [159,160,161]. The gene discussed is TMEM88; the disease is hepatocellular carcinoma.