TMEM43 and cardiac arrhythmia: The authors’ proposed the reason may be two-fold: (1) exposing the TMEM43 KI mice to long-term endurance exercise; and (2) a possible lower probability of ventricular arrythmias occurring at the onset of disease due to small size of mouse hearts, based on previous reports that demonstrated self-termination of electrically induced ventricular arrythmias in rodents [21,144].