IFNG and peripheral arterial disease: mCRP also binds strongly to endothelial and other cell-derived microparticles, inducing monocyte polarization towards M1 (pro-inflammatory/CD206+), in association with T-helper (TH2) derived production of interferon-gamma (IFNγ); furthermore, a strong correlation was found between LDL-c levels and mCRP bound to endothelial microparticles in individuals with PAD [28].