CVD major risk factors (smoking, hypertension, hyperlipidemia, hyperglycemia) also induce oxidative stress increase, which promotes pro-inflammatory cytokines synthesis, chemokines (MCP-1), and adhesion molecules (ICAM-1, VCAM-1) through nuclear factor κB (NF-κB) pathway induction. This evidence concerns the gene NFKB1 and Hyperglycemia.