EPCAM and Familial prostate cancer: In another prostate cancer study, the overexpression of the epithelial cell adhesion molecule (EpCAM) significantly elevated the phosphorylation levels of key PI3K/AKT/mTOR pathway molecules, including p-AKT, p-mTOR, and p-ribosomal protein S6 kinase (S6K), further activating this pathway.