Particularly, TP53 rs1042522, NF-kB rs28362491, IL-10 rs1800896, IL-16 rs11556218 and FOXP3 rs3761549, as well as ESR1 rs9340799 and rs2234693 SNPs, are not associated with the co-occurrence of endometriosis and RA, AS or SS. The gene discussed is ESR1; the disease is rheumatoid arthritis.