Cen et al. [59] showed an association of rs28362491 polymorphism with SLE and a gene-to-gene interaction between NFKB1 rs28362491 and TNIP1 rs3792783 SNPs, thus indicating their synergistic contribution to the increased predisposition of SLE [59]. The gene discussed is TNIP1; the disease is systemic lupus erythematosus.