SH2D3C and diabetic cardiomyopathy: Additionally, proteins such as VDAC1, VDAC2, and CKMT1B, which are associated with mitochondrial function and energy transport, were enriched in pathways like diabetic cardiomyopathy (Figure 2a, light green color) and metabolic pathways, highlighting the impact of nsP3 on mitochondrial dynamics and cellular energetics.