Sarcoidosis patients had decreased levels of IL-1β, IL-5, IL-8, IL-12p70, TNF-α, angiogenin, C3a, C4a, RANTES, and MCP-1 and increased levels of IL-2, IL-4, IL-6, IL-13, IFN-γ, and VEGF. This evidence concerns the gene C3 and sarcoidosis.