This study aimed to explore the phytochemical constituents, antioxidant capacities, and anticancer activities of ethanol extracts obtained from the hydrodistillation residue of S. aromaticum (SA) and the seeds of S. nervosum (SN), using two colorectal cancer cell lines with different p53 statuses—wild-type HCT116 and mutant HT-29. This evidence concerns the gene TP53 and colorectal cancer.