This hypothesis is supported by our results that showed in NSCLC cells an sEV-dependent upregulation of EMT-related genes (vimentin, SMAD3) and cadherin switch (E-cadherin reduction and N-cadherin increase) that occurred via an autocrine mechanism and that is hindered by blocking integrin α5β1 signaling. This evidence concerns the gene SMAD3 and non-small cell lung carcinoma.