These shuttles have fundamental roles in both physiological and pathological processes and here we explore their function in cancer progression and resistance to therapy by EMT activation and immune modulation in a specific subtype of NSCLC, the EGFR mutant one, that is known to develop features of EMT and immune evasion under resistance to targeted agents [46,49,50]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.