MMP3 and rheumatoid arthritis: In an RA mouse model, during joint inflammation, the downregulation of collagens (COL1A1, COL3A1, and COL5A1) accompanied by an increase in metalloproteases (MMP3 and MMP11), and the downregulation of enzymes involved in matrix degradation, such as ADAMTS1 and ADAMTS2 (a disintegrin and metalloprotease with thrombospondin motifs), were observed [221].