TGFB1 and rheumatoid arthritis: An intensive and important process in the early stage of RA is angiogenesis (the development of new blood vessels), which is regulated by many inducers and inhibitors along with the involvement of pro-angiogenic factors like acidic and basic fibroblast growth factors (FGFs), transforming growth factor (TGF)-β, angiopoietin, placental growth factor, and vascular endothelial growth factor (VEGF) [243,244].