Hedyotis diffusa Willd modulated its anti-inflammatory targets (TNF-α, IL-6, IL-17, and IL-10) in vitro through the suppression of the PI3K/AKT signaling pathway, thus revealing its anti-RA capacity at varying concentrations between 0.5 and 2.0 mg/mL [20]. Here, TNF is linked to rheumatoid arthritis.