Differentially methylated patterns of B lymphocytes were observed in RA and systemic lupus erythematosus (SLE) patients, and in the control group, CpG sites were located in the CD1C, TNFSF10, PARVG, NID1, DHRS12, ITPK1, ACSF3, and TNFRSF13C genes [65]. This evidence concerns the gene ITPK1 and systemic lupus erythematosus.