The Qi-Sai-Er-Sang-Dang-Song decoction (in concentrations ranging from 0.25 to 4%) inhibited RA symptoms with a focus on inflammation by inhibiting IL-6 and -18 and -1β that are regulated by the Notch/NF-κB axis [315]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.