TNF and rheumatoid arthritis: The ethanol extract of Achyranthes aspera L. (with doses ranging from 100 to 300 μg/mL) revealed its potential as a natural anti-inflammatory remedy in the treatment of RA by the downregulation of the mRNA expression levels of inflammatory genes, blocking NF-kB promoter activity induced by TNF-α and the inactivation of two upstream signaling molecules, such as Src and Syk kinases [289].