Jolkinolide B (an ent-abietane-type diterpenoid found in Euphorbia plants) revealed its anti-RA potential at a 1 μM concentration through the suppression of TNF-α and IL-6 by decreasing the protein expression level of the JAK2/STAT3 pathway in vitro [295]. The gene discussed is JAK2; the disease is rheumatoid arthritis.