Similarly, the decreased expression of MMP-1 and -3 and pro-inflammatory factors (IL-1 and IL-6) and the elevated level of the pro-apoptotic factor (Bax nd cleaved caspase 3) inhibited RA-FLs invasion via the inactivation of the WNT/β-catenin signaling pathway [233]. Here, MMP1 is linked to rheumatoid arthritis.