The mechanism of the anti-RA activity of Siweixizangmaoru decoction (with doses ranging from 12.5 to 400 μg/mL) from Tibet was revealed to include the modulation of TNF-α; IL-1β, -6, -4, and -10; MMP-2, -3, and -9; and MMP-13 through the suppression of JAK2/STAT3 and NF-κB signaling [161]. This evidence concerns the gene STAT3 and rheumatoid arthritis.