NFKB1 and rheumatoid arthritis: However, the downregulation of miR-10a in RA-FLs accelerated NF-κB activation and significantly promoted the production of various inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, MCP-1, and matrix metalloproteinase (MMP)-1 and MMP-13 [73].