CD177 and rheumatoid arthritis: MMPs have a critical role in RA since they degrade ECM to destroy the integrity of synovial, cartilage, and bone tissue through the selective cleavage of many non-matrix components present in the extracellular environment, such as cell surface receptor, cytokines, chemokines, cell–cell adhesion molecules, clotting factors, and other proteinases like binding proteins to be involved in inflammation and immunity in RA [213,214].