A comprehensive analysis of DNA methylation in RA-SFs identified 1 859 differently methylated loci, of which hypomethylated ones such as CHI3L1, CASP1, STAT3, MAP3K5, MEFV, and WISP3 were of critical importance and found to be involved in cell migration, adhesion, transendothelial penetration, and interactions in the extracellular matrix [62]. The gene discussed is STAT3; the disease is rheumatoid arthritis.