Proteomic profiling identified a set of six proteins with predictive value for SCD in patients with hypertrophic cardiomyopathy (HCM): thrombospondin-1 (THBS1), complement C3 (C3), aldolase A (ALDOA), Ras suppressor protein 1 (RSU1), glutathione S-transferase omega 1 (GSTO1), and talin-1 (TLN1). Here, C3 is linked to hypertrophic cardiomyopathy.