Notably, LEF treatment significantly reduced CD8+ T cell counts to 7.66 ± 2.08 cells/HPF, compared to the vitiligo model group (37.67 ± 3.05 cells/HPF; p < 0.0001; Figure 2A), underscoring its capacity for the targeted inhibition of pathogenic CD8+ T cell recruitment. Here, CD8A is linked to vitiligo.