CD8A and vitiligo: Finally, the flow cytometric analysis of peripheral blood mononuclear cells (PBMCs) revealed a marked decrease in the frequency of IFN-γ+ CD8+ T cells after in vivo LEF treatment: 10.47 ± 0.72% of the IFN-γ+ CD8+ T cell population in the vitiligo model group compared to only 6.76 ± 0.30% in LEF-treated mice (p < 0.0001; Figure 2C, Supplementary Figure S1).