IGHE and asthma: To study this in vivo, we adapted a previously described a mast cell-dependent model of asthma developed by Nakae et al. that involves repeated i.p. sensitization with ovalbumin (OVA) followed by intranasal (i.n.)challenge and is characterized by airway inflammation, allergen-specific IgE production, and bronchial hyperresponsiveness [3,4].