Along with elevated IL-13 transcripts in the lung, we observed IgG-suppressible induction of IL-4 and increases in Gata3+ T cells in OVA-treated mice, both indicators of a local Th2 dominant response to allergen, a response that underlies the airway hyperresponsiveness that is the physiologic hallmark of asthma. The gene discussed is IL4; the disease is asthma.