Furthermore, APOE ε4 non-carriers exhibited a stronger correlation between plasma p-tau217 and all CSF AD biomarkers, particularly the Aβ42/40 ratio (r = −0.731, p < 0.001, N = 142), compared to APOE ε4 carriers (r = −0.466, p < 0.001, N = 92) (Supplementary Table S4). The gene discussed is APOE; the disease is Alzheimer disease.