Similarly, Ying et al., using an in vivo model of atherosclerosis, found that liraglutide effectively reduced lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expression in aortic endothelial cells and decreased oxidative stress and inflammation in LDL receptor-deficient (LDLR-KO) mice. This evidence concerns the gene LDLR and atherosclerosis.