Additionally, semaglutide treatment reduced the expression of genes of chemokine (C-X-C motif) ligand 2 (Cxcl2), S100 calcium binding protein A8 (S100a8), and S100 calcium binding protein A9 (S100a9) [102] in murine models of obesity and vascular inflammation. The gene discussed is S100A8; the disease is obesity due to melanocortin 4 receptor deficiency.