IL6 and melanoma: In melanoma, the activation of the CAFs phenotype in normal fibroblasts is driven by melanoma cells secreting: interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), fibroblast growth factor 2 (FGF-2), fibroblast growth factor 19 antisense (FGF-19as), microRNA-211 (miR-211), and microRNA-155 (miR-155).