TRAIL is a pro-apoptotic molecule present in the cytoplasm that, upon activation of dendritic cell via toll-like receptor 7 (TLR7) and toll-like receptor 9 (TLR9) receptors, can be exposed on the cell surface and induce tumor cell death through interaction with death receptors: TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [84]. This evidence concerns the gene TNFSF10 and neoplasm.