Blocking IL-27 (using antibodies against its p28 subunit) reduced the number of CD4+ T-lymphocytes in the tumor microenvironment (TME), likely due to decreased expression of C-X-C chemokine receptor 3 (CXCR3) on CD4+ T-cells, a receptor responsible for their migration to tumors. The gene discussed is IL27; the disease is neoplasm.