Normal fibroblasts can inhibit tumor development by secreting interleukin-6 (IL-6), interleukin-15 (IL-15), transforming growth factor beta (TGF-β), pigment epithelium-derived factor (PEDF), tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and whey acidic protein four-disulfide core domain 1 (WFDC1) [30]. This evidence concerns the gene IFNG and neoplasm.