Our investigation provides compelling evidence for the clinical utility of the TNF-α (−238, rs361525) polymorphism as a predictive biomarker in sepsis-associated acute kidney injury (S-AKI), aligning with and extending the meta-analytical findings of Zhang et al. and Wang et al. [41,42], which reported increased sepsis susceptibility in Asian populations (OR = 1.49). The gene discussed is TNF; the disease is Sepsis.