m6A methyltransferase (METTL3) overexpression in mouse stroke models increases NEDD4L levels, and NEDD4L reduces intracellular iron accumulation through the ubiquitination and degradation of transferrin receptor (TFRC) and subsequently alleviates brain damage after strokes by inhibiting neuronal damage and ferroptosis [89]. Here, METTL3 is linked to Stroke.