SLC2A1 and endothelial dysfunction: In line with these prior studies, we found reduced GLUT-1 blood vessels and a smaller GLUT-1 positive area in LDLr−/−.Leiden mice, especially in the HFD+C fed LDLr−/−.Leiden group, demonstrating that both groups of LDLr−/−.Leiden mice had endothelial dysfunction [37].