CD4 and neoplasm: It was demonstrated in a study that N6-methyladenosine-associated long non-coding RNAs were significantly correlated with the clinical staging [71], survival prognosis, and tumor progression in esophageal cancer by modulating the tumor microenvironment, immune cell infiltration, CD4 memory resting T cells and M2 macrophages, and activity of critical signaling pathways, focal adhesion, and riboflavin metabolism.