EIF2AK3 and hepatocellular carcinoma: In addition to identifying the RCF targets CypA and B as mediators of RCF + Ixz efficacy, we suggest that the dual effect on the UPR to maintain XBP1s expression and protein synthesis (PERK/P-eIF2α) in HCC but not in non-cancer cells/tissues provides an important cancer-specific effect (Figure 6).