For example, splicing modulators in cohesin-mutated AML led to BRCA2 exon 12 skipping and an associated reduction in BRCA2 levels, with a corresponding increase in chemosensitivity [57], revisiting the previously suggested redundancy of BRCA exon 12, as exon 12 has been shown to be non-essential for survival [58,59,60]. This evidence concerns the gene BRCA2 and acute myeloid leukemia.