BRCA2 and Hereditary breast and ovarian cancer syndrome: FA caused by biallelic pathogenic variants (PVs) in BRCA2/FANCD1 (OMIM *600185) accounts for only about 3% of FA cases [3,5], but it is clinically significant because it relates the underlying FA/BRCA pathway defect to hereditary breast and ovarian cancer (HBOC), due to monoallelic BRCA2 PVs [6].