In contrast, De Roo et al. found that TGF-β2 was increased in phakic FECD eyes compared to cataract controls and also in pseudophakic FECD eyes compared to pseudophakic non-FECD edematous corneas, suggesting that elevated TGF-β2 is characteristic of FECD [44]. This evidence concerns the gene TGFB2 and Fuchs endothelial corneal dystrophy.