It is likely that both TGF-β1 and TGF-β2 contribute to FECD, as Okumura et al. have also found increased expression of TGF-β1 and TGF-β2 isoforms and their receptors in the corneal endothelium of FECD patients undergoing Descemet membrane endothelial keratoplasty (DMEK) compared to non-FECD donor controls [33]. Here, TGFB1 is linked to Fuchs endothelial corneal dystrophy.