PRMT1 and cancer: These results were also confirmed by univariate Cox regression analysis, estimating a hazard ratio (HR) of 3.05 (p < 0.001) for colorectal adenocarcinoma recurrence in patients with tumors overexpressing circ-PRMT1, as well as an HR of 4.39 (p < 0.001) for cancer-related death, in contrast to those with lower levels of circ-PRMT1 (Table 2).