In the current study, prompted by the multifaceted role of PRMT1 in epigenetic and transcriptional dysregulation, the established clinical significance of particular splice variants of this gene in various human cancers including colon cancer [21,25], and the recent discovery of circ-PRMT1 and its variants, we examined its potential clinical significance in colorectal adenocarcinoma, the most frequent type of CRC, after developing a sensitive and accurate molecular assay for its specific quantification. This evidence concerns the gene PRMT1 and colonic neoplasm.