The haploinsufficiency of RAI1 in Vglut2+ neurons is associated with motor delays, obesity, and, when RAI1 is absent, learning deficits (Figure 7A–C); meanwhile, in Gad2+ neurons, RAI1 loss leads to learning deficits (Figure 7B). This evidence concerns the gene SLC17A6 and obesity due to melanocortin 4 receptor deficiency.