Upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, CD20+ T cells from HD produced IL-4, IL-17, TNF-α, and IFN-γ more readily than CD20− T cells [5,13]; in the sub-analyses, CD4+CD20+ T cells produced more IL-4, IL-17, and TNF-α than their CD8+ counterpart, whereas CD45RO+CD20+ T cells produced more TNF-α than the CD45RA+ counterpart [5]. This evidence concerns the gene MS4A1 and Huntington disease.