Similarly, in a PP-MS cohort from another study, CSF concentration of MBP significantly correlated with the prevalence of CSF CD8+CD20+ (p = 0.0005, rs = 0.53), but not with CD4+CD20+ frequency or CSF total count of CD4+ or CD8+ T cells, suggesting a key role of CD8+CD20+ T cells in CNS demyelination, hence potentially identifying encephalitogenic T cell clones [32]. The gene discussed is MS4A1; the disease is myeloid sarcoma.